Type 3 Diabetes, also known as Alzheimer’s-related diabetes or insulin resistance of the brain, is a relatively new term that describes the Type 3 Diabetes, also known as Alzheimer’s-related diabetes or insulin resistance of the brain , is a relatively new term that describes the link between insulin resistance and Alzheimer’s disease.
Characteristics:
- Insulin resistance in the brain: Similar to type 2 diabetes, but affecting brain cells.
- Impaired glucose metabolism: Brain cells become less responsive to insulin, leading to reduced glucose uptake.
- Cognitive decline: Associated with Alzheimer’s disease, including memory loss, confusion, and dementia.
Causes and risk factors:
- Aging
- Family history of Alzheimer’s
- Obesity
- Sedentary lifestyle
- High blood pressure
- High cholesterol
- Diabetes (types 1 and 2)
- Traumatic brain injury
Symptoms:
- Memory loss
- Confusion
- Difficulty with problem-solving
- Mood changes (depression, anxiety)
- Communication difficulties
Diagnosis:
- Imaging tests (MRI, PET)
- Cerebrospinal fluid analysis
- Blood tests (glucose, insulin, amyloid beta)
- Cognitive assessments (MMSE, MoCA)
Treatment and prevention:
- Lifestyle modifications:
- Regular exercise
- Balanced diet
- Weight management
- Stress reduction
- Medications:
- Acetylcholinesterase inhibitors (e.g., donepezil)
- Memantine
- Insulin sensitizers (e.g., metformin)
- Alternative therapies:
- Omega-3 fatty acids
- Curcumin
- Vitamin D
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